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About the conditions

The MPS Society supports individuals affected by 27 rare lysosomal storage diseases. This includes the seven Mucopolysaccharide (MPS) diseases, Fabry and related diseases such as Mucolipidosis (ML), LAL D, GM 1 Gangliosidosis and more.

Lysosomes are the recycling plants of our cells.  When working normally they continuously break down old materials to be recycled. In Lysosomal Storage Disorders (LSDs) this process no longer works the way it should.

When the Lysosomes are not working in the way that they should, old materials build up in the cells and, over time, cause damage. This damage results in the progressive signs and symptoms we see in the conditions that we support.

You can find out more about the individual conditions we support below:

Alpha-Mannosidosis

Alpha-mannosidosis is a rare lysosomal storage disease of the glycoprotein family of diseases and is closely related to mucopolysaccharidoses, the disease...
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Aspartylglycosaminuria

Aspartylglycosaminuria (AGU) is one of the oligosaccharides storage diseases. AGU was first described by Dr Pollitt and others in 1968.Read on for...
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Beta-Mannosidosis

Beta-mannosidosis is a rare lysosomal storage disease of the glycoprotein family of diseases and is closely related to mucopolysaccharidoses....
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Fabry

On this page you can find our animated guide, general information about the condition, latest news, updates and stories and a list of relevant resources...
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Farber disease

Farber disease is a rare, progressive disease caused by a deficiency (reduced function) of an enzyme called acid ceramidase. Farber disease is also...
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Free Sialic Acid Storage Disease

Free sialic acid storage diseases (free SASDs) are rare inherited lysosomal storage diseases. There are three forms of free SASDs; an infantile form...
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Fucosidosis

Fucosidosis is one of the oligosaccharides storage diseases, it was first described by Dr Durand in 1966.Read on for information about the condition or...
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Gaucher

Gaucher disease is a lysosomal storage disease. 
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Geleophysic dysplasia

Geleophysic dysplasia is a very rare progressive disease which comes under a group of diseases related to the mucopolysaccharidoses.Read on for...
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GM1 Gangliosidosis

GM1 gangliosidosis is an inherited lysosomal storage disease that progressively destroys nerve cells (neurons) in the brain and spinal cord.Read on for...
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Lysosomal Acid Lipase Deficiency (LAL D)

Lysosomal acid lipase deficiency (LAL D) is a rare genetic disease that is characterised by problems in the breakdown and use of fats and cholesterol in...
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Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disease that progressively destroys nerve cells (neurons) in the brain and spinal...
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MPS conditions

Mucopolysaccharide (MPS) conditions are a family of rare, life limiting lysosomal storage disorders that can affect both children and adults....
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MPS I Hurler, Hurler Scheie and Scheie

On this page you can find our animated guide, general information about the condition, latest news, updates and stories and a list of relevant resources...
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MPS II Hunter

On this page you can find our animated guide, general information about the condition, latest news, updates and stories and a list of relevant resources...
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MPS III Sanfilippo

On this page you can find general information about the condition, latest news, updates and stories and a list of relevant resources and events.
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MPS IV Morquio

On this page you can find general information about the condition, latest news, updates and stories and a list of relevant resources and events.
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MPS IX Natowicz

On this page you can find general information about the condition, latest news, updates and stories and a list of relevant resources and events.
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